We evaluated the hypothesis of whether higher dietary magnesium intake is associated with reduced colorectal tumour risk.
A case-control study on colorectal adenomas (768 cases; 709 polyp-free control subjects) and a meta-analysis of colorectal adenomas (3 case-control studies) and carcinomas (6 prospective cohort studies) were conducted. Dietary magnesium was estimated from food-frequency questionnaires in the case-control study and most studies in the meta-analyses. Data analysis comprised multiple logistic regression analysis (case-control study) and fixed- and random-effects meta-analyses.
Our findings support the hypothesis that higher intakes of dietary magnesium are associated with lower risk of colorectal tumours. The consumption of magnesium-rich foods may be a new avenue to explore further in the search for cancer-prevention strategies.